<?xml version="1.0" encoding="UTF-8"?><CodeSystem xmlns="http://hl7.org/fhir"><id value="definition-method"/><meta><lastUpdated value="2026-03-31T18:55:04.283+00:00"/></meta><text><status value="generated"/><div xmlns="http://www.w3.org/1999/xhtml"><p class="res-header-id"><b>Generated Narrative: CodeSystem definition-method</b></p><a name="definition-method"> </a><a name="hcdefinition-method"> </a><p>This case-sensitive code system <code>http://hl7.org/fhir/definition-method</code> defines the following codes:</p><table class="codes"><tr><td style="white-space:nowrap"><b>Code</b></td><td><b>Display</b></td><td><b>Definition</b></td></tr><tr><td style="white-space:nowrap">systematic-assessment<a name="definition-method-systematic-assessment"> </a></td><td>Systematic Assessment</td><td>Any method of routinely determining whether or not specific outcomes (e.g. adverse events) have occurred, for example through a standard questionnaire, regular investigator assessment, regular laboratory testing, or other method</td></tr><tr><td style="white-space:nowrap">non-systematic-assessment<a name="definition-method-non-systematic-assessment"> </a></td><td>Non-Systematic Assessment</td><td>Any non-systematic method for determining whether or not adverse events have occurred, such as self-reporting by participants or occasional assessment/testing</td></tr><tr><td style="white-space:nowrap">mean<a name="definition-method-mean"> </a></td><td>Mean</td><td>Aggregated using mean of observed values.</td></tr><tr><td style="white-space:nowrap">median<a name="definition-method-median"> </a></td><td>Median</td><td>Aggregated using median of observed values.</td></tr><tr><td style="white-space:nowrap">mean-of-mean<a name="definition-method-mean-of-mean"> </a></td><td>Mean of Means</td><td>Aggregated using mean of means (e.g. study mean values).</td></tr><tr><td style="white-space:nowrap">mean-of-median<a name="definition-method-mean-of-median"> </a></td><td>Mean of Medians</td><td>Aggregated using mean of medians (e.g. study median values).</td></tr><tr><td style="white-space:nowrap">median-of-mean<a name="definition-method-median-of-mean"> </a></td><td>Median of Means</td><td>Aggregated using median of means (e.g. study mean values).</td></tr><tr><td style="white-space:nowrap">median-of-median<a name="definition-method-median-of-median"> </a></td><td>Median of Medians</td><td>Aggregated using median of medians (e.g. study median values).</td></tr></table></div></text><extension url="http://hl7.org/fhir/StructureDefinition/structuredefinition-wg"><valueCode value="fhir"/></extension><extension url="http://hl7.org/fhir/StructureDefinition/structuredefinition-standards-status"><valueCode value="informative"/></extension><extension url="http://hl7.org/fhir/StructureDefinition/structuredefinition-fmm"><valueInteger value="1"/></extension><url value="http://hl7.org/fhir/definition-method"/><identifier><system value="urn:ietf:rfc:3986"/><value value="urn:oid:2.16.840.1.113883.4.642.4.1953"/></identifier><version value="6.0.0-ballot4"/><name value="DefinitionMethod"/><title value="Definition Method"/><status value="active"/><experimental value="false"/><date value="2020-12-28T16:55:11+11:00"/><publisher value="HL7 (FHIR Project)"/><contact><telecom><system value="url"/><value value="http://hl7.org/fhir"/></telecom><telecom><system value="email"/><value value="fhir@lists.hl7.org"/></telecom></contact><description value="The method used to define, describe, or determine a characteristic value."/><jurisdiction><coding><system value="http://unstats.un.org/unsd/methods/m49/m49.htm"/><code value="001"/><display value="World"/></coding></jurisdiction><caseSensitive value="true"/><valueSet value="http://hl7.org/fhir/ValueSet/definition-method"/><content value="complete"/><concept><code value="systematic-assessment"/><display value="Systematic Assessment"/><definition value="Any method of routinely determining whether or not specific outcomes (e.g. adverse events) have occurred, for example through a standard questionnaire, regular investigator assessment, regular laboratory testing, or other method"/></concept><concept><code value="non-systematic-assessment"/><display value="Non-Systematic Assessment"/><definition value="Any non-systematic method for determining whether or not adverse events have occurred, such as self-reporting by participants or occasional assessment/testing"/></concept><concept><code value="mean"/><display value="Mean"/><definition value="Aggregated using mean of observed values."/></concept><concept><code value="median"/><display value="Median"/><definition value="Aggregated using median of observed values."/></concept><concept><code value="mean-of-mean"/><display value="Mean of Means"/><definition value="Aggregated using mean of means (e.g. study mean values)."/></concept><concept><code value="mean-of-median"/><display value="Mean of Medians"/><definition value="Aggregated using mean of medians (e.g. study median values)."/></concept><concept><code value="median-of-mean"/><display value="Median of Means"/><definition value="Aggregated using median of means (e.g. study mean values)."/></concept><concept><code value="median-of-median"/><display value="Median of Medians"/><definition value="Aggregated using median of medians (e.g. study median values)."/></concept></CodeSystem>