<DetectedIssue xmlns="http://hl7.org/fhir"><id value="ddi"/><text><status value="generated"/><div xmlns="http://www.w3.org/1999/xhtml">
      <p><b>Severity: High</b> - Risk of internal bleeding</p>
      <p>Those who take acetaminophen along with the widely used blood-thinning drug warfarin may face the risk of serious internal bleeding. People on warfarin who take acetaminophen for at least seven days in a row should be closely watched for bleeding.</p>
      <ul>
        <li><a href="MedicationStatement/tylenol">500 mg Acetaminophen tablet 1/day, PRN since 2010</a></li>
        <li><a href="MedicationRequest/warfarin">Warfarin 1 MG TAB prescribed Jan. 5, 2014</a></li>
      </ul>
      <p>Mitigation: Jan 5, 2014 by Dr. Adam Careful: </p>
      <p>Asked patient to discontinue regular use of Tylenol and to consult with clinician if they need to resume to allow appropriate INR monitoring</p>
    </div></text><status value="final"/><category><coding><system value="http://terminology.hl7.org/CodeSystem/v3-ActCode"/><code value="DRG"/><display value="Drug Interaction Alert"/></coding></category><code><coding><system value="http://terminology.hl7.org/CodeSystem/v3-ActCode"/><code value="DRG"/><display value="Drug Interaction Alert"/></coding></code><severity><coding><system value="http://hl7.org/fhir/detectedissue-severity"/><code value="high"/><display value="High"/></coding></severity><subject><reference value="Device/example"/></subject><identifiedDateTime value="2014-01-05"/><implicated><reference value="MedicationStatement/example001"/><display value="500 mg Acetaminophen tablet 1/day, PRN since 2010"/></implicated><implicated><reference value="MedicationRequest/medrx0331"/><display value="Warfarin 1 MG TAB prescribed Jan. 15, 2015"/></implicated><detail value="Risk of internal bleeding.  Those who take acetaminophen along with the widely used blood-thinning drug warfarin may face the risk of serious internal bleeding. People on warfarin who take acetaminophen for at least seven days in a row should be closely watched for bleeding."/><mitigation><action><coding><system value="http://terminology.hl7.org/CodeSystem/v3-ActCode"/><code value="13"/><display value="Stopped Concurrent Therapy"/></coding><text value="Asked patient to discontinue regular use of Tylenol and to consult with clinician if they need to resume to allow appropriate INR monitoring"/></action><date value="2014-01-05"/><author><reference value="Practitioner/example"/><display value="Dr. Adam Careful"/></author></mitigation></DetectedIssue>